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Kepple A, Cernek PK "Amlodipine-induced acute intermittent porphyris exacerbation.

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Missing even one dose can lead to a significant rise in blood pressure, which could lead to other serious health issues.

Certain other drugs may interact with amlodipine and benazepril or should not be used at the same time.

Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin.

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New clinical trial data, from the phase 4 Sevitension Study, will be presented at the 23rd European Meeting on Hypertension and Cardiovascular Protection (ESH) in Milan, comparing FDC treatment olmesartan and amlodipine with perindopril and amlodipine in reducing central aortic blood pressure.

Concomitant use of aliskiren and olmesartan in patients with diabetes mellitus.

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Adults: The usual initial antihypertensive oral dose of amlodipine besylate tablets is 5 mg once daily with a maximum dose of 10 mg once daily.

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Elderly patients and patients with hepatic insufficiency have decreased clearance of amlodipine with a resulting increase in AUC of approximately 40 to 60%, and a lower initial dose may be required.

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Adverse events were similar to those seen in adults.

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