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Within the first 90 minutes of a complete ureteral obstruction, afferent preglomerular arteriolar vasodilation occurs, which temporarily increases renal blood flow.
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Prostaglandins serve to dilate the afferent arteriole; by blocking this prostaglandin-mediated effect, particularly in renal failure, NSAIDs cause unopposed constriction of the afferent arteriole and decreased RPF (renal perfusion pressure).
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Intermittent vaso-occlusive crises may be superimposed, or chronic low-level pain may be the only expression of the disease.
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Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
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Others require frequent doses of opiod analgesics.
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The name presumably comes from the fact that it is a derivative coming from a species.
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Also, know what your hospital's policy is for administration of all of the medications listed above.
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In all of these, when using an NSAID alone, even when dosed prior to surgery, outcomes are not as impressive as one would hope (Table 1).
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