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Although combinatorial chemistry in one or more of its manifestations has now been present as a discovery source for approximately 80% of the time covered by this review, to date, we still can only find one formal de novo new chemical entity reported in the public domain, with a second possibility discovered in a similar manner, with both approved for drug use.
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It works by making the pancreas produce insulin and less glucagon and also by helping the body to make better use of the insulin it produces (effect of metformin).
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